• Rezolute, Inc. (NASDAQ:RZLT) saw its price plummet by 87.93% following a failed Phase 3 study, sparking an investigation by Holzer & Holzer, LLC.
• Oriental Culture Holding Ltd. (NASDAQ:OCG) experienced an 81.95% decrease in stock price, amidst releasing its unaudited financial results for the first half of 2025.
• C3is Inc. (NASDAQ:CISS) and GRI Bio, Inc. (NASDAQ:GRI) also faced significant declines of 79.82% and 54.70%, respectively, due to various factors including industry challenges and public offering pricing.

In the recent market update, several companies have experienced significant price movements, reflecting a range of underlying factors that have influenced their stock performance. Here's a consolidated analysis of the top losers in the market, based on the provided JSON data. Rezolute, Inc. (NASDAQ:RZLT) saw its price plummet to $1.32, marking an astonishing 87.93% decrease. This drastic drop comes despite the company's focus on developing transformative therapies for metabolic diseases. Holzer & Holzer, LLC is conducting an investigation into Rezolute to determine if the company complied with federal securities laws. This follows Rezolute's announcement that its Phase 3 sunRIZE study failed to meet both the primary and key secondary endpoints, leading to a drop in the company's stock price.

Oriental Culture Holding Ltd. (NASDAQ:OCG) experienced a significant decline, with its price falling to $1.57, an 81.95% decrease. The company, known for its online platform facilitating e-commerce trading of artwork and collectibles in China, saw its volume reach 8,830,648. This sharp decline could be related to market sentiment or potentially company-specific developments that have yet to be disclosed. Oriental Culture released its unaudited financial results for the first half of 2025, ending June 30, which may have influenced investor sentiment.

C3is Inc. (NASDAQ:CISS), a provider of international seaborne transportation services, saw its stock price drop to $0.34, a 79.82% decrease. With a trading volume of 9,457,494, this movement might reflect broader industry challenges or specific issues within the company. C3is reported its unaudited financial and operating results for the third quarter and the first nine months of 2025. The company highlighted that its handysize dry bulk carriers are on short-term charters, generating steady cash flows, while its Aframax tanker is achieving voyage charter rates of approximately $52,000 per day in the spot market.

GRI Bio, Inc. (NASDAQ:GRI), a clinical-stage biopharmaceutical company, witnessed its price decrease to $0.54, a 54.70% fall. This decline occurred amidst a trading volume of 7,557,967, suggesting investor reactions to recent company developments or broader market trends affecting the biotech sector. GRI Bio announced the pricing of an $8 million public offering, which includes 10,666,667 shares of common stock and Series F warrants, each priced at $0.75. The offering is expected to close around December 12, 2025, pending customary closing conditions.

Thunder Power Holdings, Inc. (OTCQB:AIEV), which develops and manufactures electric vehicles, saw its stock price decrease to $0.14, a 49.58% drop. This movement, on a relatively low volume of 800, might indicate specific concerns or developments within the company or its industry sector. Thunder Power reported its third-quarter 2025 financial results and is accelerating the integration of its Taiwan assets and expanding its renewable energy portfolio, resulting in a tenfold increase in solar capacity. The company is also taking initial steps toward relisting on NASDAQ. These significant price movements highlight the volatility within various sectors, including biotechnology, e-commerce, marine shipping, and electric vehicle manufacturing. Factors contributing to these declines could range from company-specific news, such as earnings reports or strategic decisions, to broader market trends and economic indicators. Investors and stakeholders will likely be closely monitoring these companies for any further developments or statements from company executives that might explain these dramatic shifts in stock performance.